【摘 要】
：
DNA quadruplexes both within gene promoter sequences and at telomeres have been extensively studied as potential small-molecule therapeutic targets[1].Formation of G-quadruplexes has been shown to inh
【机 构】
：
Key Laboratory of Chemical Biology of Hebei Province,College of Chemistry and Environmental Science,
【出 处】
：
第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会
论文部分内容阅读
DNA quadruplexes both within gene promoter sequences and at telomeres have been extensively studied as potential small-molecule therapeutic targets[1].Formation of G-quadruplexes has been shown to inhibit the activity of telomerase,which plays a pivotal role in the proliferation and has become a potential therapeutic target in oncology.Ligands that facilitate G-quadruplex formation and subsequently inhibit telomerase activity could be potential anticancer drugs.A large number of small molecule G-quadruplex binders have emerged since the early reports of telomerase inhibition from the laboratories of Hurley and Neidle,in most cases,the ligands contain large flat aromatic systems which interact with a G-tetrad platform via π-π stacking[2].
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