Background: Pathogenesis of atherosclerosis is a mystery wrapped in controversy, the earliest stages of the development of atherosclerosis are mediated, in large part, by the inflammatory cascade was generally accepted.The compensatory mechanism between monocytes and neutrophils in CHD patients is associated with LDL oxidation and is expected to become an early diagnostic marker of AS.We investigated the Transcriptional profiling of the native LDL-stimulated THP-1 for further study the relationship of LDL oxidation and the prevention and diagnosis ofatherosclerosis.