Introduction In this work we introduce bioanalytical applications previously realized on lab-on-chip devices that have been successfully transferred to the field of open mcrofluidics (OM).Open microfluidic systems are microfluidic networks on planar substrates without being enclosed by solid interfaces and thus not having rigid boundaries [1].Applications in open microfluidic systems can be conducted on-demand with often less amounts of reagents required.Furthermore, time consuming & cost intensive fabrication of microchips can be omitted using planar low-cost polymer substrates.In this work we present DNA and protein electrophoresis as well as microbatch protein crystallization in an open microfluidic environment.