【摘 要】
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Cancer stem cells (CSC) are a subset of cancer cells that share the characteristics of self-renewal capacity and multipotency with stem cells.CSC produces daughter cells with differential nature and t
【机 构】
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School of Life Sciences, Sun Yat-sen University China
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Cancer stem cells (CSC) are a subset of cancer cells that share the characteristics of self-renewal capacity and multipotency with stem cells.CSC produces daughter cells with differential nature and thus contributes to tumor.The presence of CSC is associated with tumor initiation and therapyresistance.The hierarchical and stochastic CSC model can explain the phenotypic and functional heterogeneity in various types of cancer.Our recent works suggest that microenvironment, which is one of crucial elements for tumorigenesis, tumor progression, neovasculogenesis and chemoresistance, is pivotal for CSC.
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