Objective:To explore the curative effect and safety of neural stem cells intrathecal transplantation for the treatment of cerebral hemorrhage.Method:4.0 × 108 neural stem cells per time were transplanted into subarachnoid space by lumbar puncture seven days after cerebral hemorrhage,twice per week,a total of four times.NIHSS scores and brain CT scan were conducted to assess patients neural functions and the volume of perihematom lesions at the first,seventh,fourteenth,twenty-first and twenty-eighth day.Result:The NIHSS scores and the volume of perihematom lesions were significantly reduce since the fourteenth day.The differences were very significant by the intra-group and between-group comparison before and after treatment (P<0.05).There were no adverse reactions except transient fever and shiver in a few patients.Conclusion:The neural stem cells intrathecal transplantation for the treatment of cerebral hemorrhage was safe and effective.