Objective: The prevalence of Peyronies Disease is 2 to 8.9%average 5%.Thus,PD is not rare disease.We will show the 17 years experience in Toho University.Methods: We had 344 cases for 17 years.The average age was 51.4 years.Chief complains were curvature,palpable fibrosis,pain,ED etc.The angle of curvature was 0 to 90 degrees.About direction of curvature,34%was upper direction,17%were left direction and lower direction,11%was right direction.One hundred and twenty cases(35%)were improved by medication.We usually use Tranilast as medication.Tranilast is used for Keloid and hypertrophic scar in Japan.The mechanism is suppression of TGF-β.Operations were performed after conservative treatment for 1 year.We had two operation methods,plication and grafting.After shaving tunica,we make inverted plication suture using nonabsorble 2-0 Tycron.We have two methods of saphenous vein graft.If plaque is small,we performed vein graft after plaque excision.If plaque is large,we performed rectangle type vein graft after Hourglass-shaped incision.We performed dermal graft for large defect and lateral defect.Results: Ninety-three cases(27%)were performed saphenous vein graft.Seven cases(2%)were performed dermal graft.Fifty-two cases(15%)were performed plication.Satisfaction rate was 91.8%.Slight curvature remain was 6.1%.Complain short penis was 2.1%.Complication rate with ED was 0%.Conclusions:(Ⅰ)Vein graft is better than plication method for Peyronies disease with penis shortening;(Ⅱ)vein is the best as material for grafting,because the grafted vein is thin and soft;(Ⅲ)the hourglass-shaped incision method is most suitable for cases of a wide plaque;(Ⅳ)we need dermal graft for large defect due to calcification of tunica and lateral defect;(Ⅴ)plication method for PD with mild or moderate ED is safety,because cavernous artery from dorsal artery is cut at dorsal grafting.