The lipoxin receptor agonist BML-111 protects against LPS/D-GalN-induced acute liver injury in rats

来源 :中国免疫学会第九届全国免疫学学术大会 | 被引量 : 0次 | 上传用户:tju515
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Objective: Lipoxins (LXs), a class of arachidonic acid metabolites, display unique anti-inflammatory and pro-resolving actions in a variety of inflammatory diseases.The present study was undertaken to investigate the effects of BML-111 (the lipoxin A4 receptor agonist) in a model of acute liver injury, and to explore the mechanisms.
其他文献
Background: Osteopontin is increased in bacterial lung infection.However, the level of osteopontin in virus-induced lung injury patients is not clear and the relationship between the hyerproduction of
Background: Scavenger receptor A (SRA) is expressed predominantly in phagocytic cells playing an essential role in the host immune defense against invading microorganisms.Our previous study reported t
研究背景:汉滩病毒HTNV感染导致的肾综合征出血热HFRS属于我国《传染病防治法》规定的乙类传染病,是临床上病情最为严重和复杂的急性感染性疾病之一.游离DNA (cell free DNA,cf-DNA)又称循环DNA,是一种广泛存在于动植物和人体液中的细胞外DNA.健康人血中cf-DNA含量很低,在机体发生肿瘤、感染、自身免疫病以及外伤和器官移植等病理情况下,体内cf-DNA的含量明显增高,但不
Background & Aims: microRNA-7 (miR-7), a member of miRNA family, which was demonstrated played important roles in various tumor diseases.Accumulating evidences suggested that distinct miRNA molecules
Cyclooxygenases (COXs) and their prostanoid products play important roles in a diverse range of physiological processes, including in the immune system.Here, we provide evidence that COX-1 is an essen
会议
Background: To investigate the plasma serological differences of anti-F antibodies between chronic and recovered infections.Methods: Subtype 1b of F or C protein was used as coated antigen to assess t
Background: Obesity-induced visceral adipose tissue (VAT) inflammation is a key factor leading to insulin resistance and type 2 diabetes.The early recruitment of CD8+ T cells into VAT has been shown t
Background: Diabetic arterial calcification has been indicated as a strong predictor of cardiovascular mortality.Vascular smooth muscle cells (VSMCs) differentiate into osteoblast-like cells plays a p
会议
Objective: LXs are a class of newly found arachidonic acid metabolites, possess potent anti-inflammatory and proresolution effects.We had previously confirmed the LXs agonists BML-111 had possessed th
背景:在机体病毒感染后的清除中,宿主免疫应答发挥了重要的作用.与抗原递呈密切相关的HLA系统,在对病毒的有效应答中起着关键作用.内质网氨肽酶1和2 (endoplasmic reticulum aminopeptidase 1 and 2,ERAP1 and ERAP2)是抗原递呈中的重要分子,已有研究报道,ERAP1基因的多态性与自身免疫性疾病、慢性感染性疾病的发生发展有着密切的关联性.目的ER