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Objective: To determine specific symptoms and describe the relationship between symptom distress and coping strategy of patients with esophageal cancer subjected to postoperative adjuvant chemotherapy.Methods: A descriptive and correlative design was used in the study.M.D.Anderson Symptom Inventory (MDASI), Medical Coping Modes Questionnaire (MCMQ), and demographic questionnaire were used to survey 84 patients undergoing postoperative adjuvant chemotherapy.SPSS13.0 was used to analyze data.