This article reported a method of coating nanoparticles with spray-drying by a series of PbO-B2O3(PB)glass.The method of coating nanoparticles with glass is different from the tradition method-solid phase method.Firstly,We used Lead acetate((CH3COO)2Pb·H2O)and Boric acid(H3BO3)which are water-solubility to be raw materials,then the powders were calcined in an oven to decompose into corresponding oxide and dont need the second ball-milling.Finally,the obtained powders were pressed at 20 MPa into disks with a diameter of 12.0 mm and thickness of 1.0 mm prior to sintering at 620 ℃ for 30min.