论文部分内容阅读
Flow microreactor technology is bringing a revolutionary change in organic chemistry.It is widely recognized that a huge number of synthetic routes make use of organometallic reagents.However,the development of flow processes using organometallics sometimes could be problematic because of their high reactivity and intrinsic chemical instability.Nevertheless,organometallic reagents have been successfully handled in flow microreactors,often with better results compared to batch mode.Our recent efforts in this field prompted us to investigate organometallic mediated transformations in integrated microflow systems.2 We focused our attention on the development of sustainable synthetic pathways employing highly reactive organometallic intermediates difficult to handle using traditional "flask-chemistry".Example of isomerizations,carboxylation and homologation reactions based on the use of organolithiums in flow conditions will be discussed.