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  5. Single patient-derived subclonal analysis of HCC reveals diverse heterogeneity link to cellular phen

Single patient-derived subclonal analysis of HCC reveals diverse heterogeneity link to cellular phen

来源 :第七届全国生物信息学与系统生物学学术大会 | 被引量 : 0次 | 上传用户：qq77880066
【摘 要】
：
Hepatocellular carcinoma (HCC) harbors intra-tumor heterogeneity from genotype to phenotype,however,heterogeneous characteristics of multiple molecular levels have not been linked to phenotypic divers
【作 者】
：
Liu S 
【机 构】
：
CAS Key Laboratory of Genomic and Precision, Beijing Institute of Genomics, Chinese Academy of Scien
【出 处】
：
第七届全国生物信息学与系统生物学学术大会
【发表日期】
：
2016年8期
【关键词】
：
HCC subclonal heterogeneity multi-omics cellular phenotype 
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　　Hepatocellular carcinoma (HCC) harbors intra-tumor heterogeneity from genotype to phenotype,however,heterogeneous characteristics of multiple molecular levels have not been linked to phenotypic diversity within single tumors.In the present study,four subclones (Pa,Pb,Ra and Rb) from one patients primary and recurrent HCC tissues were successfully obtained by primary cell culture.
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