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Background: Penis allotransplantation might be a viable option for patients who need penis reconstruction.In this study, we present an experimental allogenic penis transplantation model in Beagles.Methods: Twenty adult Beagles were allocated into 10 pairs for penile transplantation.After operation, the skin and balanus were observed;if adverse symptoms occurred, the transplanted penis was resected and pathologically examined.Frequency of urination, urinary stream, and patency level were recorded 7 days after transplantation.Cystourethrography was performed on Day 10.The transplanted penises were resected on Day 14 for pathological examination.Results: Mean vascular anastomosis time was 70.95 ± 8.95 min, mean operation time was 133.00 ± 10.31 min, and mean blood loss was 135.75 ± 41.40 ml.Two penises were pale and showed swelling on Day 1.Three transplanted penises showed balanus necrosis, black skin, and mild tissue swelling on Day 3.Three showed black color of the balanus but no tissue swelling on Day 5.In the remaining 12 beagles, the incisions healed well, and the catheters were removed on Day 7: normal urination and linear urinary stream were observed,without urethra stenosis.Pathological examination on Day 14 showed that they had a normal structure, without interstitial edema and with normal and functional blood vessels.Conclusion: Transplanted penises survived after allotransplantation, and the dogs regained urination ability.Penis autotransplantation in Beagles is feasible.This preliminary study shows a potential for application of this new procedure for penis transplantation in humans.