【摘 要】
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Objective: To determine whether and how Tie2 expression on myeloid cells promote tumor resistance to chemotherapy.Methods: Transplanted tumor was treated with various chemotherapeutic drugs.Vascular a
【机 构】
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Institute of Biophysics,Chinese Academy of Sciences,Beijing,China
【出 处】
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22nd Asia Pacific Cancer Conference(第22届亚太抗癌大会)
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Objective: To determine whether and how Tie2 expression on myeloid cells promote tumor resistance to chemotherapy.Methods: Transplanted tumor was treated with various chemotherapeutic drugs.Vascular and myeloid staining patterns were determined by immunohistochemisty.Tumor growth after chemotherapy was observed by conditionally depleting Tie2 genes in myeloid cells, and the mechanisms of action were investigated.Results: Abnormal angiogenesis around the necrotic area,companied by accumulated Tie2-expressing macrophages,occurred during the repair phase after chemotherapy.Depletion of the Tie2 gene in lysozyme-positive macrophages impaired the necrosis-associated angiogenesis and markedly restrained tumor regrowth after chemotherapy.Tie2 expression was also induced on infiltrated CD 11b+Ly6C+ macrophages by hypoxia resulting from chemotherapy.
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