Hepatocellular carcinoma(HCC) is an aggressive and life-threatening disease which caused enormous number of deaths worldwide in 2008.Limited success of current treatments reveals an urgent need for a more effective therapeutics.Literature has highlighted Aurora kinases as potential targets because they frequently overexpress in HCC patients and their expression is associated to with poor clinical outcome.Our aim is to develop novel small-molecule inhibitor to Aurora kinases with the hope to ameliorate disease burden.On the basis of our previous work on multikinase inhibitor,scaffold hopping strategy led to discovery of new bioisostere of critical ureido linker.