【摘 要】
：
U12,one of 20 derivatives synthesized from ursodeoxycholic acid (UDCA),has been found to have anticancer effects in liver cancer cell lines (SMMC-7721 and HepG2) and to protect normal liver cells from
【机 构】
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School of Pharmaceutical Sciences, Xiamen University, Xiamen, Fujian, PR China
【出 处】
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华东地区第十四届实验动物科学学术交流会
论文部分内容阅读
U12,one of 20 derivatives synthesized from ursodeoxycholic acid (UDCA),has been found to have anticancer effects in liver cancer cell lines (SMMC-7721 and HepG2) and to protect normal liver cells from deoxycholic acid (DCA) damage (QSG-7701).Its anticancer mechanism was investigated using computer-aided network pharmacology and comparative proteomics.Results showed that its anti-malignancy activities were activated by mTOR/S6K1,cyclinD1/CDK2/4 and caspase-dependent apoptotic signaling pathways in hepatocellular carcinoma cells (HCC).The action of U12 may be similar to that of rapamycin.
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