Bleomycin,a widely used cancer drug,may give rise to a serious side effect,pulmonary fibrosis which is associated with significant morbidity and mortality.Despite the intensive efforts,the precise pat
Rheumatoid arthritis(RA)is a common chronic autoimmune inflammatory disorder.The role of autophagy and apoptosis in the pathogenesis of RA is intricate.Interleukin-22(IL-22)as a cytokine of Th22 plays
It is widely demonstrated that aberrantly expressed lncRNAs are associated with various cancers,but it is still uncertain how they may become coordinated during the gastric carcinogenesis.Here,we repo
Chitinase-h(Chi-h)is of special interest among insect GH18 chitinases due to its exclusive distribution in lepidopteran insects,one of the most destructive crop pests.Proteomic analysis of insect molt
In spite of being a commensal for healthy individuals,Candida albicans can rapidly switch to pathogenic mode featured with hyphal development,altered cell wall composition and secreted virulence facto
OBJECTIVE: To investigate the value of subunit 3 of molecular chaperone TRiC(CCT3)to determine its function in esophageal carcinoma(EC)progression.METHODS: CCT3 expression levels were examined in EC c
Recent studies have shown that PD-1/PD-L1 checkpoint blockade is a dramatic therapy for melanoma through enhancing antitumor immune activity.Currently,major strategies for PD-1/PD-L1 blockade have mai
Phosphorylation is a major type of post-translational modification,which can influence the cellular physiological function.Atg4B,a key autophagy-related protein,has a potential effect on the survival
Background: Colorectal cancer(CRC)has one of the highest rates of cancer-related mortality,and investigating novel chemo-therapeutic approaches are significant in the treatment of colorectal cancer.Gl