【摘 要】
：
CD40 ligation has been shown to promote antigen-presenting functions of dendritic cells, which express CD40 receptor.Here we reported significantly altered biodistribution and immune responses with th
【机 构】
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Department of Biochemistry University of Ottawa Canada
【出 处】
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BIT Life Sciences 1st Annual World Cancer Congess-2008(2008中
论文部分内容阅读
CD40 ligation has been shown to promote antigen-presenting functions of dendritic cells, which express CD40 receptor.Here we reported significantly altered biodistribution and immune responses with the use of CD40 targeted adenovirus.Compared with unmodified adenovirus 5, the CD40-targeted adenovirus following intravenous administration (i.v.) resulted in increased transgene expressions in the lung and thymus, which normally do not take up significant amounts of adenovirus.Intradermal injection saw modified adenovirus being mainly processed in local draining lymph nodes and skin.Following intranasal administration (i.n.), neither unmodified nor targeted viruses were found to be in the liver or spleen, which predominantly took up the virus following i.v.administration.
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