Targets of Somatic Hypermutation within Immunoglobulin Genes in Zebrafish

来源 :2011第三届中国北京抗体大会 | 被引量 : 0次 | 上传用户:QQ2009sunboy
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  In mammals, somatic hypermutation (SHM) ofimmunoglobulin (Ig) genes is critical for the generation of high affinity antibodies and effective immune responses.Knowledge of sequence specific biases in the targeting of somatic mutations can be useful to studies aimed to understand antibody repertoires produced in response to infections, B cell neoplasms, or autoimmune disease.To evaluate potential nucleotide targets of somatic mutation in zebrafish, we constructed an enriched cDNA library of IgL VJ-C segments from which randomly selected clones were sequenced and analyzed.
其他文献
  Multiple sclerosis (MS) is an autoimmune disease of CNS, resulting in demyelination, axon loss, and development of disability.Autoantibodies (autoAbs) in MS
会议
  High titers, specificity, ability to neutralize toxic compounds, affinity and avidity are intrinsic qualities required for antibodies antivenom of snakes.Th
会议
[摘 要] 本文简要的分析了企业物资采购成本的组成,阐述了对物资采购成本控制的相关认识,从影响物资采购成本的条件、物资采购流程控制进行了探讨和深究,从这些基本问题中整理出降低物资采购成本的几点应对措施。并提出了物资采购管理中降低成本,并且总结出了物资采购管理中降低成本,必须要树立物资采购全成本控制的新理念。  [关键词] 物资采购成本 采购流程控制 全成本控制的理念  物资采购成本是
  Background: Anti-SSa antibodies are useful in the diagnosis of autoimmune disease, particularly primary and secondary Sjogrens Syndrome.They are also found
会议
  In recent years, DNA chips have revolutionized genome research.A similar trend is predicted for peptide chips in proteome research.They can be applied for e
会议
  Anchored periplasmic expression (APEx) is a method for isolating high affinity ligand-binding proteins from large combinatorial libraries, and antibodies hi
会议
期刊
  Seven transmembrane receptors are important drug targets and exhibiting multiple functional behaviors in response to natural and synthetic ligands.A traditi
会议
  The challenge, following the sequencing of the human genome, is the functional decryption of the human proteome.Specific binders to every human protein are
会议
  Autoimmune hepatitis (AIH) is a type of chronic hepatitis of unexplained etiology.It has been strongly suggested that autoimmune mechanisms are closely invo
会议