【摘 要】
：
随着全球经济的快速发展,生活水平的日益提高,高热量高脂肪食物的过多摄入,以及体力劳动的减少,肥胖症的发病率与日俱增.据不完全统计,目前全世界肥胖症发病人数已近5亿,每年因肥胖症促成的直接或间接死亡人数达30万,并有可能成为21世纪的头号杀手.随着人类基因组测序的完成,寻找导致肥胖的遗传因素是目前科学界研究的热点问题.FTO (Fat Mass and Obesity Associated)基因是目
【机 构】
：
郑州大学化学与分子工程学院,郑州,450001
【出 处】
：
中国化学会第十届全国天然有机化学学术会议
论文部分内容阅读
随着全球经济的快速发展,生活水平的日益提高,高热量高脂肪食物的过多摄入,以及体力劳动的减少,肥胖症的发病率与日俱增.据不完全统计,目前全世界肥胖症发病人数已近5亿,每年因肥胖症促成的直接或间接死亡人数达30万,并有可能成为21世纪的头号杀手.随着人类基因组测序的完成,寻找导致肥胖的遗传因素是目前科学界研究的热点问题.FTO (Fat Mass and Obesity Associated)基因是目前科学界找到的第一个确切与广泛人群肥胖有关的基因1-4.在小鼠做的基因敲除实验、点突变以及过表达结果也显示了FTO可能是治疗与预防肥胖的非常重要的靶标5,6.
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