【摘 要】
:
微生物来源的天然产物是药物先导化合物的重要资源库1.基于"基因水平传递"2、"内共生理论"3和生物防御主导的"协同进化"3等理论,共生微生物能够产生与宿主相同或相似的活性化合物,成为获取结构和生物活性多样性天然产物的重要资源.,内生菌作为独特化学结构和良好生物活性的天然产物新来源,具有重要的研究潜力5,6.
【机 构】
:
三峡大学生物与制药学院,天然产物研究与利用湖北省重点实验室,宜昌,443002
【出 处】
:
中国化学会第十届全国天然有机化学学术会议
论文部分内容阅读
微生物来源的天然产物是药物先导化合物的重要资源库1.基于"基因水平传递"2、"内共生理论"3和生物防御主导的"协同进化"3等理论,共生微生物能够产生与宿主相同或相似的活性化合物,成为获取结构和生物活性多样性天然产物的重要资源.,内生菌作为独特化学结构和良好生物活性的天然产物新来源,具有重要的研究潜力5,6.
其他文献
In recent years, the secondary metabolites of mangrove habitat microorganism also become an important resource for drug research.We screened a fungus which had significant cytotoxic activity and chrom
According to cooperative interactions, the co-cultivation or mixed fermentations of two or more microbes represents a promising approach for stimulating physiological conditions and activating silent
The whole plan of Kinostemon ornatum (Hemsl) Kudo has been used as a folk medicine for the treatment of cancer, hepatitis in China.Five new compounds, kinostemon A (1), kinostemon B (2), 15-methoxy-ki
Tyrosinase inhibitors and antioxidants are becoming increasingly important in the cosmetic and medicinal industries due to their preventive effects in pigmentation disorders and skin aging1.Prunus tom
双斑獐牙菜具有抗糖尿病活性,为阐明双斑獐牙菜治疗糖尿病的化学物质基础,对双斑獐牙菜全草的90%乙醇提取物进行了研究.醇提物分别用石油醚、乙酸乙酯、正丁醇萃取.石油醚部位经反复硅胶柱层析、重结晶等方法,分离得到4个化合物(1-4)(见图1),利用波谱数据并结合参考文献对其结构进行了鉴定,均为已知化合物,其中化合物2和4为首次从该植物中分离得到.
目的:Apratoxin A是从海洋蓝藻中分离得到的一种具有强抗肿瘤活性的大环内酯肽类化合物.对人鼻咽癌KB细胞株和人结肠癌LoVo细胞株的IC50值分别为0.52 nM和0.36 nM.该化合物结构中包含了由四个天然氨基酸组成的四肽片段、新颖的α,β-不饱和半胱氨酸结构构成的手性噻唑啉环片段和含有四个手性中心的长链脂肪酸Dtena片段.
Adenosine derivatives have significant sedative and hypnotic activity1,2.Five 2-deoxy-adenosine derivatives (4a-4e) and five adenosine derivatives (5a-5e) were synthesized, and accessed for their seda
Neutrophil gelatinase associated lipocalin (Ngal), was originally found from neutrophil granule as a complex to gelatinase B (matrix metalloproteinase 9, MMP9) and thus got its name.It can stabilize t
Screening of antimicrobial and antitumor agents from marine microorganisms is one of the hot spots for the research of marine drugs and screening models play important roles in this study.The authors
A novel SHP2 inhibitor-fumosorinone (Fumos) from entomogenous fungi was discovered;it possesses the selective inhibition for Shp2 over other PTPs (PTP1B, TCPTP, Shpl, HePTP, Lyp,STEP, PTPH1, PTPRA, Cd