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Alpha-conotoxin (α-CTx) TxIB is a uniquely selective ligand,which blocks α6/α3β2β3 nicotinic acetylcholine receptor (nAChR) with an IC50 of 28 nM.In contrast,the peptide showed little or no block of other tested subtypes.α6/α3β2β3 nAChRis a potential therapeutic target for the treatment of several neuropsychiatfic diseases,including drug addiction and Parkinson disease.Therefore,α-CTx TxIB is a valuable therapeutic candidate peptide.