Chemical Synthesis and comparison of the yield of different Oxidative Folding methods of a-Conotoxin

来源 :10th IST Asia Pacific Congress on Animal , Plant and Microbi | 被引量 : 0次 | 上传用户：Ling_cheng

【摘要】

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【作者】

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Xiaosa Wu Yong Wu DongtingZhangsun SulanLuo

【机构】

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Key Laboratory of Tropical Biological Resources,Ministry of Education;Key Lab for Marine Drug of Hai

【出处】

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10th IST Asia Pacific Congress on Animal , Plant and Microbi

【发表日期】

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2014年5期

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Alpha-conotoxin (α-CTx) TxIB is a uniquely selective ligand,which blocks α6/α3β2β3 nicotinic acetylcholine receptor (nAChR) with an IC50 of 28 nM.In contrast,the peptide showed little or no block of other tested subtypes.α6/α3β2β3 nAChRis a potential therapeutic target for the treatment of several neuropsychiatfic diseases,including drug addiction and Parkinson disease.Therefore,α-CTx TxIB is a valuable therapeutic candidate peptide.

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Chemical Synthesis and comparison of the yield of different Oxidative Folding methods of a-Conotoxin

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