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Objective To study six common variants (rs7903146,rs12255372,rs11196218,rs12775879,rs290487,rs290481) of TCF7L2 gene in a Chinese population,and to determine whether these variants are also risk factors of type 2 diabetes mellitus (T2DM) and impaired glucose regulation (IGR).Methods In this case-control study,all the subjects underwent an oral glucose tolerance test (OGTT).