【摘 要】
：
Aim: To investigate the effect of complement activation of the alternative pathway on human microvascular endothelial ceils and provide potential targets for intervention and drug screening.Methods: N
【机 构】
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The Key Laboratory of Chemistry for Natural Products, Guizhou Province and Chinese Academy of Scienc
【出 处】
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The 12th Meeting of the Asia Pacific Federation of Pharmacol
论文部分内容阅读
Aim: To investigate the effect of complement activation of the alternative pathway on human microvascular endothelial ceils and provide potential targets for intervention and drug screening.Methods: Normal human serum complement was activated by cobra venom factor.After exposure of endothelial cells to activated complement for various times, expression of adhension molecules, chemokine, and fibrinolytic activity, the activation of NF-κB, p38MAPK, and JAK2, and intervention by inhibitors were assayed.LDH, caspase-8, NO, and cell viability were also measured.
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