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The pathways of protein post-translational modification (PTM) and histone epigenetic code plays crucial roles in various pathophysiological conditions, while their impacts on immune system are poorly understood.The substrates of PTM regulative enzymes and their specific inhibitors including HDAC, HMT, kinase and E3 ligase are well demonstrated as effective anti-cancer drugs for personalized medicine, nevertheless how to comprehensively screen the biomarker and targets of those enzymes and corresponding inhibitors in immune system remains great challenges.