【摘 要】
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Objective: A meta-analysis was performed to derive a more precise evaluation of the relationship between XRCC1 Arg399Gln polymorphism and glioma risk.Methods: we searched the PubMed,EMBASE,and Web of
【机 构】
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Department of Neurosurgery, Chinese PLA General Hospital, 28 Fuxing RD, Beijing 100853, China
【出 处】
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湖北省抗癌协会青年委员会第五届青年学术论坛
论文部分内容阅读
Objective: A meta-analysis was performed to derive a more precise evaluation of the relationship between XRCC1 Arg399Gln polymorphism and glioma risk.Methods: we searched the PubMed,EMBASE,and Web of Science and extracted 12 eligible studies with 4,062 glioma cases and 5,302 glioma-free controls for this meta-analysis.The pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to assess the strength of the association.Results: In the overall analysis,we found that the XRCC1 Arg399Gln polymorphism was statistically associated with the risk of glioma (ORGG vs.AG + AA = 0.90,95%CI = 0.84-0.97,Pheterogeneity = 0.020; ORallele G vs.allele A = 0.96,95%CI = 0.91-1.00,Pheterogeneity = 0.110).We also observed significant association between XRCC1 Arg399Gln polymorphism and glioma risk in Asian populations.Conclusion: The results of the meta-analysis suggested a decreased susceptibility to glioma in association with the XRCC1 Arg399Gln polymorphism.Yet it is necessary to conduct future prospective explorations to gain a better insight into the impact of XRCC1 Arg399Gln polymorphism on glioma risk.
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