【摘 要】
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Swine share many anatomic and physiologic characteristics with humans which make them one of the primary translational research models.In particular swine display similar physiology to humans for the
【机 构】
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Department of Comparative Medicine Medical University of South Carolina USA
【出 处】
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中国上海第七届国际新药发明科技年会
论文部分内容阅读
Swine share many anatomic and physiologic characteristics with humans which make them one of the primary translational research models.In particular swine display similar physiology to humans for the cardiovascular,digestive,urologic and dermatologic systems.The characteristics which make them an applicable model for biomedical research also make them a suitable model for many aspects of toxicological studies.Reactions of the heart and vascular system to test substances are closely related to similar reactions in humans.Swine are true omnivores and process ingested substances in a similar fashion.The cytochrome P-450 system has both similarities and differences.They have similar oxidative biotransformation,high glucuronidation,high acetylation and low sulfation activities.Pig skin is used for transdermal toxicology studies because of similar anatomy,cellular turnover time,permeability,and absorption characteristics.The multirenculate,multipappilate kidneys are more similar to humans in anatomy and physiology than other common lab animals.In addition fetal pharmacology and toxicology studies have been performed in this species because of the transplacental passage characteristics of test substances.This species does require unique approaches to chronic catheterization and oral administration techniques which will be detailed.
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