【摘 要】
:
The application of vaccines to cancer is nowadays an attractive possibility thanks to advances in molecular engineering and a better understanding of tumor immunology.Transgenic animal models have pla
【机 构】
:
Merck Research Laboratories-IRBM Italy
【出 处】
:
中国上海第七届国际新药发明科技年会
论文部分内容阅读
The application of vaccines to cancer is nowadays an attractive possibility thanks to advances in molecular engineering and a better understanding of tumor immunology.Transgenic animal models have played a critical role in establishing basic paradigms of tumor immunology because they provide an in vivo milieu that cannot be reproduced in vitro.As novel immunotherapies and cancer vaccines have been developed,animal models have also played an important role in pre-clinical testing for therapeutic efficacy.Most of the current studies are performed in rodents.However,scaling up experimental protocols from rodents to humans is often not a straightforward procedure,and this particularly applies to cancer vaccines,where vaccination technology must be especially effective to overcome a variety of immune suppressive mechanisms.
其他文献
Obesity and its co-morbidities such as diabetes,coronary heart disease and cancer are a fast growing health threat in today s society.Despite great efforts,pharmacotherapy of obesity has achieved litt
Insulin resistance is a central metabolic defect of type 2 diabetes.As our studies strongly indicate ectopic accumulation of lipids as a primary cause of insulin resistance,we investigated different a
Decline in skeletal muscle mass and function occurs in older men and women.Age-associated loss of muscle increases risk of functional limitations,falls,fractures,loss of independence and poor quality
The growth hormone secretagogue receptor (GHSR) is a GPCR whose natural ligand is the 28 amino acid peptide ghrelin.Ghrelin agonism of the GHSR in the CNS leads to growth hormone (GH) secretion and in
Using genome-wide association-and large-scale replication analyses we have convincingly mapped 30 loci (17 novel) that contribute to variation in lipoprotein concentrations and created a genetic risk
Background:Epidemiological studies suggest that hyperglycemia abrogates gender based cardiovascular protection possibly associated with estrogens.Objectives:The objectives of our study were to investi
Glucose is the main energy source for the mammalian brain.It is transported from the blood to the brain across the endothelial cells of the blood-brain barrier and into the neurons and glia.This trans
Celiac disease is a pathologic immune reaction to ingested gluten proteins of wheat,rye and barley.In subjects with genetic predisposition,gluten-derived gliadin peptides induce chronic intestinal inf
With a 2-3% lifetime risk,endometrial carcinoma (EC) is the most common gynecologic malignancy in developed countries,and the incidence and mortality is increasing.There is hence a major need to devel
Toll-like receptors (TLRs) 7,8,and 9 belong to a family of pathogen-associated molecular pattern (PAMP) recognition receptors.These receptors have been shown to be expressed in endosomal membranes of