【摘 要】
：
The application of vaccines to cancer is nowadays an attractive possibility thanks to advances in molecular engineering and a better understanding of tumor immunology.Transgenic animal models have pla
【机 构】
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Merck Research Laboratories-IRBM Italy
【出 处】
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中国上海第七届国际新药发明科技年会
论文部分内容阅读
The application of vaccines to cancer is nowadays an attractive possibility thanks to advances in molecular engineering and a better understanding of tumor immunology.Transgenic animal models have played a critical role in establishing basic paradigms of tumor immunology because they provide an in vivo milieu that cannot be reproduced in vitro.As novel immunotherapies and cancer vaccines have been developed,animal models have also played an important role in pre-clinical testing for therapeutic efficacy.Most of the current studies are performed in rodents.However,scaling up experimental protocols from rodents to humans is often not a straightforward procedure,and this particularly applies to cancer vaccines,where vaccination technology must be especially effective to overcome a variety of immune suppressive mechanisms.
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