【摘 要】
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Odorant signals are perceived by binding of odor molecules to odorant receptors (ORs) that belong to the G-protein-coupled receptor (GPCR) family.The ORs activate stimulatory G-proteins thereby leadin
【机 构】
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Department Evolutionary Neuroethology Max Planck Institute for Chemical Ecology Jena Germany
【出 处】
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中国上海第七届国际新药发明科技年会
论文部分内容阅读
Odorant signals are perceived by binding of odor molecules to odorant receptors (ORs) that belong to the G-protein-coupled receptor (GPCR) family.The ORs activate stimulatory G-proteins thereby leading to enhanced cAMP production which gates cyclic nucleotide-gated ion channels and depolarizes the odorant receptor neuron.Insect OR proteins are 7-transmembrane segment proteins as GPCRs but they lack any sequence similarity to other GPCRs and show an inverted orientation in the plasma membrane.Insect ORs form heterodimers composed of an odor-specific OR protein and an ubiquitously expressed chaperone protein (as Drosophila Or83b).As previously shown,odorant stimulation of OR protein couples expressed in HEK293 cells activates nonselective cation currents via both an ionotropic and a metabotropic pathway (Wicher et al.,Nature 452 (2008) 1007).Expression of Or83b alone provided functional ion channels insensitive to odorants,but directly activated by intracellular cAMP or cGMP.
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