【摘 要】
：
TP53 is a transcription factor that plays a pivotal role in the process of DNA repair and apoptosis.In 10-20% of patients with chronic lymphocytic leukemia (CLL), the TP53 pathway is affected by genom
【机 构】
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Laboratory for Molecular Diagnostics Chambon Inc.Czech Republic
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TP53 is a transcription factor that plays a pivotal role in the process of DNA repair and apoptosis.In 10-20% of patients with chronic lymphocytic leukemia (CLL), the TP53 pathway is affected by genomic TP53 mutations, aberrant mRNA splicing or by the dysfunction of cooperating protein partners.Though there are a few known hot-spot mutations with proven biological functions, there are still a number of TP53 mutations, for which biological functions have not yet been assessed.
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