【摘 要】
：
The senescence-accelerated prone mouse (SAMP8) is an accelerated aging model.Abnormalities at the gene and protein levels have been found in SAMP8 mice,but
【机 构】
：
The Department of Biology, the Chinese University of Hong Kong
【出 处】
：
2007 Enzyme Engineering Conference(国际酶工程学术会议)
论文部分内容阅读
The senescence-accelerated prone mouse (SAMP8) is an accelerated aging model.Abnormalities at the gene and protein levels have been found in SAMP8 mice,but little information on the epigenetic,especially histone PTMs,have been reported.In the present study,we have investigated the histone PTMs in different parts of the brain of the 3-month and 12-month old SAMP8 mouse using matrix-assisted laser desorption ionization tandem time-of-flight (MALDI-TOF/TOF) mass spectrometry combined with nano-High Performance Liquid Chromatography (nano-HPLC).Specific phosphorylation at H2B serine 38,acetylation at H2B lysine 43,methylation at H2A arginine 88,and dimethylation at H3 lysine 36 were observed in the 12-month old SAMP8 mouse.Our data should definitely provide valuable information on understanding the epigenetic mechanism during aging.
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