Hyphenated techniques such as GC or LC combined with mass spectrometry provide a unique combination of separation and detection power.With its ease-of-use and lower cost, GC/MS and LC/MS with single quadrupole MS have become the workhorse instruments in many areas.Typically operating at unit mass resolution, these instruments have only been able to perform analysis with nominal mass accuracy, not enough for the determination of elemental composition of unknown compounds, which conventionally calls for the more expensive higher resolution MS systems.