抑郁症模型小鼠视网膜神经节细胞melanopsin蛋白的变化及机制

来源 :2014中华医学会第十二次全国精神医学学术会议 | 被引量 : 0次 | 上传用户:LYXTTKX
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目的 目前对抑郁症的研究发现,抑郁症一个非常重要的特征就是具有明显的昼夜节律性而且昼夜失调也是抑郁症重要的诱因,这都提示昼夜节律机制在抑郁症发病中的左右.因此,昼夜节律异常很有可能是抑郁症重要的发病机制.而在昼夜节律的调控中,视网膜神经节细胞上的melanopsin视黑质蛋白已经被证明是关键性的因素.因此melanopsin很有可能在抑郁症的发病中起着重要作用.因此本课题就要研究抑郁症时melanopsin的改变及作用机制.
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