【摘 要】
：
Acetylcholinesterase inhibitors are the most frequently prescribed anti-Alzheimers drugs.A series of 7H-thiazolo[3,2-b]-1,2,4-triazin-7-one derivatives as the dual binding site acetylcholinesterase in
【机 构】
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Key Laboratory of Structure-Based Drug Design & Discovery,Ministry of Education,Shenyang Pharmaceuti
【出 处】
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全国药物化学学术会议暨第四届中英药物化学学术会议
论文部分内容阅读
Acetylcholinesterase inhibitors are the most frequently prescribed anti-Alzheimers drugs.A series of 7H-thiazolo[3,2-b]-1,2,4-triazin-7-one derivatives as the dual binding site acetylcholinesterase inhibitors were designed based on virtual screening methods.The target compounds were synthesized in satisfactory yields,and the synthetic pathway was described in Scheme 1,and were characterized with elemental analysis,IR,MS,1H-NMR and 13C-NMR.The biological evaluation against human acetylcholinesterase in vitro showed all target compounds exhibit good activities for AChE inhibition using the Ellman method.
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