Objectives:Fear memory is one of the core symptoms in Post-Traumatic Stress Disorder (PTSD) development.However,currently there is minimal understanding about the effective treatment toward the fear memory itself,particularly the blockade of the fear memory retrieval process.Prior research has revealed that glucocorticoids modulate memory function.In particular,glucocorticoids enhance fear memory consolidation in an inverted U curve fashion.Here we used fear conditioning paradigm to study the effect of glucocorticoids on context and auditory cue-dependent fear memory retrieval.Methods:Fear conditioning paradigm is established by using 0.5 mA with two pairing footshock apart 60 sec in between,and the animals were tested 24 hours later in both context and cue-dependent fashion.