【摘 要】
：
Background The aim of the present study was to assess the effects of rosuvastatin on contrast-induced nephropathy(CIN) in diabetic nephropathy rats.Methods Male SD rats, using a single intraperitoneal
【机 构】
：
Department of Cardiology,Institute of Cardiovascular Research of People's Liberation Army,Shenyang
论文部分内容阅读
Background The aim of the present study was to assess the effects of rosuvastatin on contrast-induced nephropathy(CIN) in diabetic nephropathy rats.Methods Male SD rats, using a single intraperitoneal injection ofstreptozotocin (STZ) to create a diabetic nephropathy model.The model rats were randomly grouped into diabetic nephropathy group, contrast group and the rosuvastatin+contrast group, 10 in each group.Intravenous injection of iopromide (3500 U/kg) was given 72 hours later, the line serum creatinine testing, to determine the CIN formation.The serum total cholesterol, triglycerides, creatinine, nitric oxide, interleukin-6, and tumor necrosis factor alpha levels were analyzed.Urine samples were taken to measure the albumin/urinary creatinine ratio.Kidneys were sectioned and stained with hematoxylin/eosin and Massons trichrome.Immunohistochemical analysis of the renal tissue was performed to detect macrophage infiltration of the glomeruli.
其他文献
Background The use of vascular closure devices (VCDs) for the reduction of access site complications following percutaneous coronary intervention (PCI) remains controversial.Patients undergoing primar
Background Ischemia/reperfusion (I/R) injury remains the major cause of cardiomyocytes loss and cardiac dysfunction.Akt,a serine/threonine kinase which mediates survival signal through the phosphoryla
Background The ventricular arrhythmia often appears with coronary artery disease, especially for acute myocardial infarction patients (AMI).The ventricular arrhythmia is an important factor to affect
Background Variant angina is caused by spontaneous coronary artery spasm.Calcium-channel antagonists and nitrates are effective in most patients, but 5％-30％ of patients are refractory to aggressive me
Background Currently, cardiac interventional radiology equipment has tended to using flat-panel detector (FPD)instead of image intensifier charge-coupled device (Ⅱ-CCD), as FPD offer better imaging pe
Background Thyroid hormone plays an important role in cardiovascular system and can influence myocardial perfusion.The purpose of this study is to explore the relationship between the level of serum t
Background To study the relationship between originate and breakout and radiofrequency catheter ablation in patients with premature ventricular contractions (PVCs) originating from the aortic sinus cu
Background Stroke is the second leading cause of death among adults worldwide.Mindin is an extracellular matrix(ECM) protein that plays important roles in regulating inflammation, angiogenesis and neu
Background Tumor necrosis factor receptor-associated factor 5 (TRAF5) is an adaptor protein of the tumor necrosis factor (TNF) receptor superfamily and the interleukin-1 receptor/Toll-like receptor su
Background Administration of loading-dose 80 mg/d atorvastatin has been proved beneficial in patients with stable coronary artery disease and acute coronary syndromes (ACS).However, little is known ab