The tumour tissue is characteristic of an acid-microenvironment (pH~6.8).This feature as well as the low pH milieu (4.5-6.5) of endosome and lysosome provides an excellent in situ trigger for ondemand anti-cancer drug delivery [1].Tailor-made amphiphilic polymer-drug conjugate has been a versatile platform for efficient drug delivery.The self-assembly of such conjugates generate micellar nanostructures differing in size,shape,and surface properties.The broad choice of polymer and conjugate linking bond (e.g.hydrazone) enable the precise deign of acid-liable conjugate micelles for enhanced chemotherapy.