【摘 要】
：
There is no cure for AIDS at this time, although, highly active antiretroviral therapy (HAART) has greatly improved the outcome of HIV/AIDS, it is limited by side effects, viral drug-resistant, and th
【机 构】
：
Core Director of Antiviral Research Laboratory, Division of Virology, City of Hope National Medical
【出 处】
：
2005 WHTS3rd Annual Congress of International Drug Discovery
论文部分内容阅读
There is no cure for AIDS at this time, although, highly active antiretroviral therapy (HAART) has greatly improved the outcome of HIV/AIDS, it is limited by side effects, viral drug-resistant, and the cost of the therapy.Gene Therapy for HIV/AIDS is suggested as a goal worth considering, and the history and current status of gene therapy for HIV/AIDS will be discussed.A diverse array of transgenes has been developed to inhibit HIV-1 replication and/or protect cells from infection.These are categorized into two types: RNA strategies (antisense, ribozyme [RZ], RNA aptamers, RNA decoys and RNA interference [RNAi]) and protein strategies (transdominant negative mutants, intrakines, toxins, single chain antibodies, and DNA-based vaccines).These can be generally delivered is two ways: in T cells and in hematopoietic progenitor cells (HPC).
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