TBX3通过促进NANOG转录而促进肝癌肿瘤干细胞的生成和功能

来源 :中国生物化学与分子生物学会第十二届会员代表大会暨2018年全国学术会议 | 被引量 : 0次 | 上传用户：hzduoying001

【摘要】

：

肝癌中的肿瘤干细胞(hepatic cancer stem cells,HCSCs)是导致肝癌发生、发展和复发的关键因素,这里我们通过调节转录因子TBX3的表达,来研究TBX3对HCSCs产生和功能的影响、及其分子机制。我们发抑制和促进TBX3表达可分别导致CD133+HCSCs的水平明显下调和上调。微球形成试验显示抑制和促进TBX3导致CD133+HCSCs的微球形成能力明显下调和上调。

【作者】

：

刘东杰刘凯

【机构】

：

首都医科大学附属北京佑安医院,北京,100069;北京市肝病研究所,北京,100069

【出处】

：

中国生物化学与分子生物学会第十二届会员代表大会暨2018年全国学术会议

【发表日期】

：

2018年10期

【关键词】

：

肝癌肿瘤干细胞 TBX3 NANOG

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TBX3通过促进NANOG转录而促进肝癌肿瘤干细胞的生成和功能

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