【摘 要】
：
2-Methoxyestradiol(2ME2),an endogenous metabolite of estradiol,has been discovered to possess antiangiogenic and antimitotic properties with lower toxicity.
【机 构】
：
School of Pharmaceutical Sciences,Zhengzhou University,Zhengzhou 450001,PRChina
【出 处】
：
2015年全国药物化学学术会议暨第五届中英药物化学学术会议
论文部分内容阅读
2-Methoxyestradiol(2ME2),an endogenous metabolite of estradiol,has been discovered to possess antiangiogenic and antimitotic properties with lower toxicity.
其他文献
Lysine specific demethylase 1(LSD1),the first identified histone lysine demethylase by Yang Shi group in 2004[1],specifically catalyzes demethylation of mono-and di-methylated lysine 4 and lysine 9 of
The p53 tumor suppressor protein plays a key role in regulation of several important cellular processes,including cell cycle,apoptosis,DNA repair and angiogenesis.
Chalcone,which exist in the Kava plant[1] aroused considerable interest recently for their various bioactivities,including anti-inflammatory,anti-microbial and especially anti-cancer activities[2].
Efavirenz,trade name Stocrin,is one of the non-nucleoside HIV-1 reverse transcriptase inhibitor which is widely used in clinic in the world.
Efonidipine is a higher and longer effective Ca2+channel blocker with L-type and T-type Ca2+channel blocking activity and is a unique antihypertensive clinical drug with renal protection.
Viruses are a kind of individual small,simple structures,containing only a single nucleic acids(DNA or RNA),which are parasitic in living cells to copy and proliferate.
第四代口服避孕药物屈螺酮，是螺内酯的类似物，具有抗盐皮质激素和抗雄性激素的活性。其药理作用类似天然孕酮，有可靠的避孕效果，除此之外，还能对一些妇科疾病如经前期综合征、多囊卵巢综合症等有很好的预防和改善的作用，也可以用来缓解钠水潴留、治疗痤疮等[1]。
Lysine specific demethylase 1(LSD1)plays an important role in the epigenetic control of gene expression and it has been found overexpressed in various tumor tissues.
泛素特异性加工酶USP28(ubiquitin specific peptidase 28,USP28)在调控DNA 损伤,转录因子的表达以及多种癌细胞中发挥着重要的作用。转录因子c-myc 依赖泛素降解,其E3 泛素化酶是SCFFbw7α,而USP28 通过识别SCFFbw7α 抑制c-myc 的降解,促进细胞增殖；此外,USP28 是DNA 损伤检查点的关键调控因子,DNA 损伤可以导致USP
凋亡是一个高度保守的过程,它对细胞的自动调节与发展至关重要。细胞调节异常是肿瘤的形成、瘤的维持以及细胞产生耐药的的基本要求[1]。调节凋亡的蛋白有两种：促凋亡蛋白(例如BAX,BAK,BAD,BIM,NOXA)和抗凋亡蛋白(例如Bcl-2,Bcl-xl,Mcl-1),两者动态结合共同控制着程序凋亡。