Synthesis and Evaluation of a Series of 1,3,4-Oxadiazoles Derivatives as Atypical Antipsychotics

来源 :第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会 | 被引量 : 0次 | 上传用户：k364709757

【摘要】

：

【作者】

：

Yin Chen Guisen Zhang

【机构】

：

Jiangsu Nhwa Pharmaceutical Co.,Ltd.69 Democratic South Road,Xuzhou,Jiangsu,221116

【出处】

：

第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会

【发表日期】

：

2012年8期

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　　Currently atypical antipsychotics cause numerous side effects,such as substantial weight gain and QT interval prolongation.The discovery of multireceptor antipsychotics that are chemically different,more effective,and free of side effects remains a challenging goal.The aim of our work is to develop novel antipsychotics that act on dopamine D2 and D3,serotonin 5-HT1A and 5-HT2A receptors with low affinity for the H1 receptors,which can effectively cure positive symptoms,negative symptoms and cognitive impairment without the weight gain side-effect.

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Synthesis and Evaluation of a Series of 1,3,4-Oxadiazoles Derivatives as Atypical Antipsychotics

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