AIM The research expounds the possibility of pereutaneous absorption of notoginsenoside R1 , in order to expand its clinical applications and provides a basis for preparation for the development of a neo-type praeparatum.METHODS We detect cumulative infiltration volume of notoginsenoside R1 in the percutaneous absorption test in vitro.RESULTS The data deled hy statistics showed that the 24-h percutaneous absorption rate of notoginsenoside R1 is about 4.35%.CONCLUSION The experiment was successful and laid the groundwork for the development of neo-type percutaneous absorption praeparatum.