Development of L-DOS47: An Antibody-enzyme Conjugate for Lung Cancer Application

来源 :2011第三届中国北京抗体大会 | 被引量 : 0次 | 上传用户:zhangwenda_gz
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  L-DOS47 is a protein conjugate consisting of a llama single chain antibody covalently bound to jack bean urease through a chemical linker.The llama antibody (AFAIKL2), obtained by recombinant expression in a T7 bacterial system, is a single domain antibody directed against the CEACAM6 antigen present on a number of tumors.The urease and AFAIKL2 antibody are chemically conjugated by a hetero-bifunctional cross linker.
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