Histologic grade is a well-established prognostic factor for breast cancer.Many trials and studies had proven its role and significance in Caucasian women.However, the relationships among histologic grade and other clinocopathologic parameters were rarely reported in a large cohort of Asian women with breast cancer.Data was collected and analysis from cancer registry of Changhua Christian hospital (CCH), Taiwan between 2002 and 2006.The collecting items include demographic characteristics, tumor characteristics and biological subtype of breast cancer.Histologic grade was scored according to the Nottingham modified Bloom-Richardson grading system.Total numbers of recurrence or death from breast cancer were ascertained after follow-up until 31, December 2007.