Scoring function is a popular computational method for predicting the protein-ligand binding affinity.It has been widely applied in modern drug discovery due to its fast and robust implementation.
The integration of ultra high-performance liquid chromatography(UHPLC),quadrupole-time of flight-mass spectrometry(Q-TOF-MS),solid phase extraction(SPE),and nuclear magnetic resonance(NMR)is a powerfu
Carbohydrate recognition is a crucial event in many biological processes and has come to the forefront of biological scientific research aiming to uncover the molecular mechanisms of many physiologica
Cyclic α-conotoxin Vc1.1(cVc1.1)(Fig 1)is an orally active peptide with analgesic activity in rat model of neuropathic pain [1].cVc1.1 has two disulfide bonds,which can have three different connectivi
Human Ether-a-go-go-Related Gene(hERG)encodes the main subunit of the rapid rectifier potassium channel that plays a critical role in the repolarization phase of cardiac action potential.Small molecul