Psoriasis is a refractory immune-mediated skin disease,and the discovery of anti-psoriatic drugs with high effectiveness and low toxicity is extremely urgent.Glycyrol(GCC),an active compound derived f
Recombinant human calcineurin B subunit(rhCNB)has been shown to be an immune-stimulatory protein promoting cytokine production and inducing phenotypic maturation of DCs.In vivo,it had a good anti-tumo
Emiliania huxleyi is the most prominent modern coccolithophore,a group of photosynthetic marine unicellular eukaryotes that play a critical role in ocean biogeochemistry.Coccolithoviruses are large do
The undisputed role of T cells in anti-tumor response has been proved by strong evidence.Redirecting T cells to tumor cells using bispecific antibodies(BsAbs)is emerging as potent cancer therapies,The
Isocitrate dehydrogenase kinase/phosphatase(AceK)is a bifunctional enzyme with both kinase and phosphatase activities that are activated by Mg2+.We have studied the interactions of Mn2+and Mg2+with Ac
利用生物信息学同源性分析吸水链霉菌基因组中链霉菌属抗生素合成调控基因,发现存在正调控基因afsR及分化负调控基因nsdA高度同源序列.全基因合成吸水链霉菌类afsR、rapG、rapH等正调控基因、类nsdA负调控基因序列,分别连接到pSET152或pKC1139表达载体,CaCl2法转入大肠杆菌ET12567(pUZ8002)中,并利用接合转移转入吸水链霉菌Y-807中,经PCR检测、检定菌抑菌
Lung cancer is one of the most common aggressive malignancies and non-small cell lung carcinoma(NSCLC)accounts for 85%of lung cancer-associated mortalities.Metastasis is common in patients with NSCLC
As a prominent viral vector,adeno-associated virus(AAV)has been used for human gene therapy for more over three decades,however,its natural cellular receptor AAVR was discovered until recently.The pro
昆虫的几丁质酶家族group I主要负责蜕皮过程中表皮几丁质降解,被认为是农药设计的潜在靶标.通过分析亚洲玉米螟几丁质酶OfChtI催化域的晶体结构,发现其活性口袋底物结合裂缝处存在一系列芳香族氨基酸,提供其与底物结合的关键疏水作用,同时也是基于结构进行选择性抑制剂筛选的重要靶点.基于以上发现,通过对比底物几丁三糖化合物结构、电荷性质对商品化合物数据库进行虚拟筛选,获得了其抑制剂TP1,TP2.
目前对生物大分子的定量研究主要采用“绝对定量”和“相对定量”的方式。但是，由于研究对象—生物体的多样性、动态性和复杂性，导致了以往研究所采用的定量体系已经不能满足于大数据时代分子生物学研究的需要。对于原始数据的产出，分子生物学研究亟需在方法学上建立新的理论体系，新的生物大分子定量规范和新的生物样本定量规范需要重新建立。在新的生物定量模式下开展定量分子生物学研究将是分子生物学的发展趋势。