【摘 要】
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Obesity is an important risk factor for many serious medical complications, which lead to impaired quality of life, considerable morbidity, premature death,
【机 构】
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CenterforHumanNutrition
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Obesity is an important risk factor for many serious medical complications, which lead to impaired quality of life, considerable morbidity, premature death, and economic burden.The most common complications of obesity involve alterations in metabolic function that are risk factors for cardiovascular disease (CVD), namely insulin resistance, diabetes, dyslipidemia (increased serum TG and decreased serum HDL-cholesterol), and increased blood pressure.Increased intrahepatic triglyceride content (IHTG;nonalcoholic fatty liver disease) is an important marker of metabolically abnormal obese people.However, not all obese persons develop metabolic complications, and ~25% of obese adults are "metabolically normal" based on insulin sensitivity measured by using the hyperinsulinemic euglycemic clamp technique.
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