【摘 要】
：
A signature prognostic marker for melanoma is the over expression of a calcium binding protein,S100B,which binds p53 and significantly lowers protein levels
【机 构】
：
UniversityofMarylandSchoolofMedicineUSA
【出 处】
：
2008中国深圳蛋白质和多肽科学大会
论文部分内容阅读
A signature prognostic marker for melanoma is the over expression of a calcium binding protein,S100B,which binds p53 and significantly lowers protein levels of the tumor suppressor.In a human strain of malignant melanoma (C8146A; wild-type p53),we demonstrate here that inhibiting S 100B protein production via siRNA (siRNAS100B) also restores functional p53 protein,phosphorylated p53,and its associated activities including apoptosis (i.e.DNA ladder formation,activation of caspase 3,PARP cleavage).
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