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为了明确常山散治疗鸡球虫病的疗效和最佳给药剂量,通过人工感染鸡柔嫩艾美耳球虫后在饲料中添加一定比例的药物,试验设常山散组(分别为0.05、0.1、0.3、0.5、0.7、1 g/kg饲料)、妥曲珠利对照组(1.0 m L/L饮水)、感染对照组和健康对照组。结果表明:与感染对照组比较,常山散各剂量组鸡盲肠和十二指肠肿胀明显减轻,血液性内容物明显减少,抗球虫指数分别为85.5、132.7、141.1、128.8、104.2和102.8,均高于感染对照组;常山散按0.1、0.3和0.5 g/kg饲料给药抗球虫指数均高于妥曲珠利对照组(124.8)。结果提示:常山散抗球虫疗效好,且作为中药提取物,绿色环保、低毒、低残留,有望成为新型抗球虫药物。
In order to clarify the efficacy of Changshan powder in treating coccidiosis and the optimal dosage, we added a certain proportion of drug to the feed by artificial infection of Eimeria tenella, and set Changshan powder group (0.05,0.1, 0.3, 0.5, 0.7 and 1 g / kg diet), and the toprapazole control group (1.0 mL / L drinking water), infected control group and healthy control group. The results showed that compared with the infected control group, the cecal and duodenal swelling of each dose group of Changshan Powder was significantly reduced, the content of blood was significantly reduced, the anti-coccidiosis index were 85.5, 132.7, 141.1, 128.8, 104.2 and 102.8 respectively, Were higher than the infected control group; Changshan powder fed 0.1, 0.3 and 0.5 g / kg feed administration coccidiosis index were higher than that of the Tropetail control group (124.8). The results suggest that Changshan Sancoccus coccidiosis has a good curative effect and is a new anti-coccidiosis drug as a traditional Chinese medicine extract, which is green, low toxicity and low residue.