【摘 要】
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Antiviral agents tend to rely upon specific interactions between the drug and a viral protein,for example sialidase inhibitors and amantadine,both of which have anti-influenza activity.This specificit
【机 构】
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Royal(Dick)School of Veterinary Studies, The University of Edinburgh, Edinburgh, EH9 1QH, UK;Institu
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Antiviral agents tend to rely upon specific interactions between the drug and a viral protein,for example sialidase inhibitors and amantadine,both of which have anti-influenza activity.This specificity has two disadvantages.Firstly,the drugs have very narrow spectra of activity and,secondly,viruses may develop resistance against them (in the case of amatadine,resistance involved a single amino acid replacement in the M2 protein).Within Chinese culture,preparations of natural materials have been used for centuries as a treatment or prophylaxis against viruses.Radix isatidis extract (PIE) has long been employed as an antiviral drug in traditional Chinese medicine,and is currently licensed in China for use as an anti-influenza agent.
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