【摘 要】
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Obiective Multiple endocrine neoplasia type 1(MEN1) is usually caused by a germline mutation in MEN1 gene encoding the tumor-suppressor protein Menin.The most frequent and initial MEN1-associated endo
【机 构】
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Key laboratory of Endocrinology of Ministry of Health,Department of Endocrinology, Peking Union Medi
【出 处】
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中华医学会第十四次全国内分泌学学术会议
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Obiective Multiple endocrine neoplasia type 1(MEN1) is usually caused by a germline mutation in MEN1 gene encoding the tumor-suppressor protein Menin.The most frequent and initial MEN1-associated endocrinopathy is primary hyperparathyroidism (PHPT).Detection of MEN 1 gene mutation prospectively in indicated patients allows for early surgical intervention and reasonable follow-up.Here, we summarized the genetic background and Menin expression status of MENl-related PHPT (MHPT) in PUMCH in the last ten years.
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